In collaboration with the Frag-MAX facility at the MAX IV synchrotron, we screen fragment libraries for binding compounds on protein crystals. Therefore we determine robust and reproducible crystallization conditions for our target proteins and screen for fragment binders by soaking the crystals. Automated pipelines of structure determination and difference map analysis give first hints for binding compounds. 

  Optimizing these initial hits further is part of our research and involves organic synthesis and peptide chemistry.