2021
Kiehstaller, S., Ottmann, C., Hennig, S.* 2021.
Bicyclic β-sheet mimetics that target the transcriptional coactivator β-catenin and inhibit Wnt signaling. Angew. Chem. Int.
Ed., 295(52):18266–18275. doi:10.1074/jbc.RA120.014708
[NCBI PubMed Entry] [download file]
2020
Kiehstaller, S., Ottmann, C., Hennig, S.* 2020.
MMP activation–associated aminopeptidase N reveals a bivalent 14-3-3 binding motif. J. Biol. Chem., 295(52):18266–18275. doi:10.1074/jbc.RA120.014708
[NCBI PubMed Entry] [download file]
Wallraven, K., Holmelin, F. L., Glas, A., Hennig, S., Frolov, A. I.*, Grossmann, T. N.* 2020.
Adapting free energy perturbation simulations for large macrocyclic ligands: How to dissect contributions from direct binding and free ligand flexibility. Chem. Sci., 11,
2269–2276. doi:10.1039/C9SC04705K
[NCBI PubMed Entry] [download file]
Lunk, I., Litty, F.-A., Hennig, S., Vetter, I. R., Kotthaus, J., Altmann, K. S., Ott, G., Havemeyer, A., Garcia, C. C., Clement, B., Schade, D.* 2020.
Discovery of N-(4-Aminobutyl)-N’-(2-methoxyethyl)guanidine as the First Selective, Nonamino Acid, Catalytic Site Inhibitor of Human Dimethylaminohydrolase
( hDDAH-1). J. Med. Chem., 63(1):425-432. doi: 10.1021/acs.jmedchem.9b01230
[NCBI PubMed Entry] [download file]
2019
Jeganathan, S., Wendt, M., Kiehstaller, S., Brancaccio, D., Kuepper, A., Pospiech, N., Carotenuto, A., Novellino, E., Hennig, S.*, Grossmann, T. N.* 2019.
Constrained peptides with fine-tuned flexibility inhibits NF-Y transcription factor assembly. Angew. Chem. Int. Ed., 58:2-10.
[NCBI PubMed Entry] [download file]
Hennig, S.*, Neubacher, S.* 2019.
Fluorescent RNA tags: current and future applications. Fut. Med. Chem., 11(19):2483-2485.
[NCBI PubMed Entry] [download file]
Neubacher, S., Hennig, S., Grossmann, T. N.* 2019.
Organisch-chemisch stabilisierte Enzyme für eine nachhaltige Wirtschaft. BIOspektrum, 25(3):338-339, doi: 10.1007/s12268-019-1039-5.
[Springer Link] [download file]
Neubacher, S., Hennig, S.* 2019.
RNA Structure and Cellular Applications of Fluorescent Light-Up Aptamers. Angew. Chem. Int. Ed., 131:1278-1291, doi: 10.1002/anie.201806482.
[NCBI PubMed Entry] [download file]
2018
Pelay-Gimeno, M., Bange, T., Hennig, S., Grossmann, T., N.* 2018.
In Situ Cyclization of Native Proteins: Structure-Based Design of a Bicyclic Enzyme. Angew. Chem. Int. Ed., 57(35):11164-11170, doi: 10.1002/anie.201804506.
[NCBI PubMed Entry] [download file]
Pospiech, N., Cibis, H., Dietrich, L., Müller, F., Bange, T., Hennig, S.* 2018.
Identification of novel PANDAR protein interaction partners involved in splicing regulation. Sci. Rep., 8(1):2798, doi: 10.1038/s41598-018-21105-6.
2017
Roszyk, L., Kollenda, S., Hennig, S.* 2017.
Using a specific RNA-protein interaction to quench the fluorescent RNA Spinach. ACS Chem. Biol., 12(12):2958-2964.
[NCBI PubMed Entry] [download file]
Krüger, D.M., Glas, A., Bier, D., Pospiech, N., Wallraven, K., Dietrich, L., Ottmann, C., Koch, O.*, Hennig, S.*, Grossmann, T., N.* 2017.
Structure-Based Design of Non-Natural Macrocyclic Peptides that Inhibit Protein-Protein Interactions. J. Med. Chem., 60:8982-8988 doi: 10.1021/acs.jmedchem.7b01221.
2015
Hennig, S., Kong, G., Mannen, T., Sadowska, A., Kobelke, S., Blythe, A., Knott, G.J., Iyer, K.S., Ho, D., Newcombe, E.A., Hosoki, K., Goshima, N., Kawaguchi, T.,
Hatters, D., Trinkle-Mulcahy, L., Hirose, T., Bond, C.S., Fox, A.H. 2015.
Prion-like domains in RNA binding proteins are essential for building subnuclear paraspeckles. J. Cell Biol., 210(4):529-539
[NCBI PubMed Entry] [download file]
Lee, C.U., Hahne, G., Hanske, J., Bange, T., Bier, D., Rademacher, C., Hennig, S., Grossmann, T. N. 2015.
Redox Modulation of PTEN Phosphatase Activity by Hydrogen Peroxide and Bisperoxidovanadium Complexes. Angew. Chem. Int. Ed., 54(46):13796-13800
[NCBI PubMed Entry] [download file]
2014
Chakravarty, D., Sboner, A., Nair, S., S., Giannopoulou, E., Li, R., Hennig, S., Mosquera, J., M., Pauwels, J., Park, K., Kossai, M., MacDonald, T., Y., Fontugne, J., Erho, N.,
Vergara, I., A., Ghadessi, M., Davicioni, E., Jenkins, R., B., Palanisamy, N., Chen, Z., Nakagawa, S., Hirose, T., Bander, N., H., Beltran, H., Fox, A., H., Elemento, O., Rubin, M., A.
2014.
The oestrogen receptor alpha-regulated lncRNA NEAT1 is a critical modulator of prostate cancer. Nature Comm., 5(5383):1-16
Milroy, L., Grossmann, T. N., Hennig, S., Brunsveld, L. and Ottmann, C. 2014.
Modulators of Protein−Protein Interactions. Chem. Rev., 114(9):4695-748
2013
Thiel, P., Röglin, L., Meissner, N., Hennig, S.,* Kohlbacher, O.* and Ottmann, C.* 2013.
Virtual screening and experimental validation reveal novel small-molecule inhibitors of 14-3-3 protein–protein interactions. Chem. Comm., 49(76):8468-70
[NCBI PubMed Entry] [download file]
2012
Kucera, N., Schmalen, I., Hennig, S., Strauss, H., Grudziecki, A., Wieczorek, C., Kramer, A. and Wolf, E. 2012. Unwinding the Differences of the Mammalian PERIOD Proteins from Crystal Structure to Cellular Function. PNAS, 109(9):3311-3316
2011
Lee, M., Passon, D. M., Hennig, S., Fox, A. H. and Bond, C., S. 2011. Construct optimization for studying protein complexes: obtaining diffraction-quality crystals of the pseudosymmetric PSPC1–NONO heterodimer. Acta Cryst. D, D67: 981–987
2010
Rose, R., Erdmann, S., Bovens, S., Wolf, A., Rose, S., Hennig, S., Waldmann, H. and Ottmann, C. 2010. Identification and Structure of Small-Molecule Stabilizer of 14-3-3 Protein-Protein Interactions. Angew. Chem. Int. Ed., 49(24): 4129-4132
2009
Hennig, S., Strauss, H., Vanselow, K., Yildiz, Ö., Schulze, S., Arens, J., Kramer, A. and Wolf, E. 2009. Structural and Functional Analyses of PAS Domain Interactions of the Clock Proteins Drosophila PERIOD and Mouse PERIOD2. PLoS Biology, 7(4): e94
2007
Schöning, J. C., Streitner, C., Page, D. R., Hennig, S., Uchida, K., Wolf, E., Furuay, M. and Staiger, D. 2007. Autoegulation of the circadian slave oscillator component AtGRP7 and regulation of its targets is impaired by a single RNA recognition motif point mutation. Plant J., 52(6):1119–1130.
Berndt, A., Kottke, T., Breitkreuz, H., Dvorsky, R., Hennig, S., Alexander, M. and Wolf, E. 2007. A Novel Photoreaction Mechanism for the Circadian Blue Light Photoreceptor Drosophila Cryptochrome. J. Biol. Chem., 282(17):13011–13021.
2005
Yildiz, Ö., Doi, M., Yujnovsky, I., Cardone, L., Berndt, A., Hennig, S., Schulze, S., Urbanke, C., Sassone–Corsi, P. and Wolf, E.* 2005. Crystal Structure and Interactions of the PAS Repeat Region of the Drosophila Clock Protein PERIOD. Mol. Cell, 17(1):69–82.