Publications


Research Articles

2022

Blanas, A., Karsjens, H., de Ligt, A., Huijbers, E., J., M., van Loon, K., Denisov, S., S., Durukan, C., Engbersen, D., J., M., Groen, J., Hennig, S., Hackeng, T., M., van Beijnum, J., R., Griffioen, A., W.* 2022.

Vaccination with a bacterial peptide conjugated to SARS-CoV-2 receptor-binding domain accelerates immunity and protects against COVID-19. iScience, 25(8):104719. doi: 10.1016/j.isci.2022.104719.

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2021

Richters, A., Hennig, S.* 2021.

Structure-driven approaches and technologies for drug discovery. Drug Discovery Today: Technologies, 40, 25-26. doi:10.1016/j.ddtec.2021.11.001.

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Gerhard, L., Hennig, S.* 2021.

FRET Analysis of RNA–Protein Interactions Using Spinach Aptamers. Methods Mol. Biol., 2323:171–197. doi:10.1007/978-1-0716-1499-0_13

  [NCBI PubMed] [Springer]

Wendt, M., Bellavita, R., Gerber, A., Efrém, N., L., Ramshorst, T. v., Pearce, N., M., Davey, P., R., J., Everard, I., Vazquez‑Chantada, M., Chiarparin, E., Grieco, P., Hennig, S., Grossmann, T., N.* 2021.

Bicyclic β-sheet mimetics that target the transcriptional coactivator β-catenin and inhibit Wnt signaling. Angew. Chem. Int. Ed., 133:14056–14063. doi:10.1002/anie.202102082
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2020

Kiehstaller, S., Ottmann, C., Hennig, S.* 2020.
MMP activation–associated aminopeptidase N reveals a bivalent 14-3-3 binding motif. J. Biol. Chem., 295(52):18266–18275. doi:10.1074/jbc.RA120.014708
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Wallraven, K., Holmelin, F. L., Glas, A., Hennig, S., Frolov, A. I.*, Grossmann, T. N.* 2020.
Adapting free energy perturbation simulations for large macrocyclic ligands: How to dissect contributions from direct binding and free ligand flexibility. Chem. Sci., 11, 2269–2276. doi:10.1039/C9SC04705K
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Lunk, I., Litty, F.-A., Hennig, S., Vetter, I. R., Kotthaus, J., Altmann, K. S., Ott, G., Havemeyer, A., Garcia, C. C., Clement, B., Schade, D.* 2020.
Discovery of N-(4-Aminobutyl)-N’-(2-methoxyethyl)guanidine as the First Selective, Nonamino Acid, Catalytic Site Inhibitor of Human Dimethylaminohydrolase ( hDDAH-1). J. Med. Chem., 63(1):425-432. doi: 10.1021/acs.jmedchem.9b01230
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2019

Jeganathan, S., Wendt, M., Kiehstaller, S., Brancaccio, D., Kuepper, A., Pospiech, N., Carotenuto, A., Novellino, E., Hennig, S.*, Grossmann, T. N.* 2019.

Constrained peptides with fine-tuned flexibility inhibits NF-Y transcription factor assembly. Angew. Chem. Int. Ed., 58:2-10.
  [NCBI PubMed] [download]

Hennig, S.*, Neubacher, S.* 2019.
Fluorescent RNA tags: current and future applications. Fut. Med. Chem., 11(19):2483-2485.
  [NCBI PubMed Entry] [download file]

Neubacher, S., Hennig, S., Grossmann, T. N.* 2019.
Organisch-chemisch stabilisierte Enzyme für eine nachhaltige Wirtschaft. BIOspektrum, 25(3):338-339, doi: 10.1007/s12268-019-1039-5.
  [Springer] [download]

Neubacher, S., Hennig, S.* 2019.
RNA Structure and Cellular Applications of Fluorescent Light-Up Aptamers. Angew. Chem. Int. Ed., 131:1278-1291, doi: 10.1002/anie.201806482.
  [NCBI PubMed Entry] [download file]

2018

Pelay-Gimeno, M., Bange, T., Hennig, S., Grossmann, T., N.* 2018.
In Situ Cyclization of Native Proteins: Structure-Based Design of a Bicyclic Enzyme. Angew. Chem. Int. Ed., 57(35):11164-11170, doi: 10.1002/anie.201804506.
  [NCBI PubMed] [download]

Pospiech, N., Cibis, H., Dietrich, L., Müller, F., Bange, T., Hennig, S.* 2018.
Identification of novel PANDAR protein interaction partners involved in splicing regulation. Sci. Rep., 8(1):2798, doi: 10.1038/s41598-018-21105-6.

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2017

Roszyk, L., Kollenda, S., Hennig, S.* 2017.
Using a specific RNA-protein interaction to quench the fluorescent RNA Spinach. ACS Chem. Biol., 12(12):2958-2964.
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Krüger, D.M., Glas, A., Bier, D., Pospiech, N., Wallraven, K., Dietrich, L., Ottmann, C., Koch, O.*, Hennig, S.*, Grossmann, T., N.* 2017.
Structure-Based Design of Non-Natural Macrocyclic Peptides that Inhibit Protein-Protein Interactions. J. Med. Chem., 60:8982-8988 doi: 10.1021/acs.jmedchem.7b01221.

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2015

Hennig, S., Kong, G., Mannen, T., Sadowska, A., Kobelke, S., Blythe, A., Knott, G.J., Iyer, K.S., Ho, D., Newcombe, E.A., Hosoki, K., Goshima, N., Kawaguchi, T., Hatters, D., Trinkle-Mulcahy, L., Hirose, T., Bond, C.S., Fox, A.H. 2015.
Prion-like domains in RNA binding proteins are essential for building subnuclear paraspeckles. J. Cell Biol., 210(4):529-539
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Lee, C.U., Hahne, G., Hanske, J., Bange, T., Bier, D., Rademacher, C., Hennig, S., Grossmann, T. N. 2015.
Redox Modulation of PTEN Phosphatase Activity by Hydrogen Peroxide and Bisperoxidovanadium Complexes. Angew. Chem. Int. Ed., 54(46):13796-13800
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2014

Chakravarty, D., Sboner, A., Nair, S., S., Giannopoulou, E., Li, R., Hennig, S., Mosquera, J., M., Pauwels, J., Park, K., Kossai, M., MacDonald, T., Y., Fontugne, J., Erho, N., Vergara, I., A., Ghadessi, M., Davicioni, E., Jenkins, R., B., Palanisamy, N., Chen, Z., Nakagawa, S., Hirose, T., Bander, N., H., Beltran, H., Fox, A., H., Elemento, O., Rubin, M., A. 2014.
The oestrogen receptor alpha-regulated lncRNA NEAT1 is a critical modulator of prostate cancer. Nature Comm., 5(5383):1-16

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Milroy, L., Grossmann, T. N., Hennig, S., Brunsveld, L. and Ottmann, C. 2014.
Modulators of Protein−Protein Interactions. Chem. Rev., 114(9):4695-748

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2013

Thiel, P., Röglin, L., Meissner, N., Hennig, S.,* Kohlbacher, O.* and Ottmann, C.* 2013.
Virtual screening and experimental validation reveal novel small-molecule inhibitors of 14-3-3 protein–protein interactions. Chem. Comm., 49(76):8468-70

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2012

Kucera, N., Schmalen, I., Hennig, S., Strauss, H., Grudziecki, A., Wieczorek, C., Kramer, A. and Wolf, E. 2012. Unwinding the Differences of the Mammalian PERIOD Proteins from Crystal Structure to Cellular Function. PNAS, 109(9):3311-3316

  [NCBI PubMed Entry] [download file]

2011

Lee, M., Passon, D. M., Hennig, S., Fox, A. H. and Bond, C., S. 2011. Construct optimization for studying protein complexes: obtaining diffraction-quality crystals of the pseudosymmetric PSPC1–NONO heterodimer. Acta Cryst. D, D67: 981–987

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2010

Rose, R., Erdmann, S., Bovens, S., Wolf, A., Rose, S., Hennig, S., Waldmann, H. and Ottmann, C. 2010. Identification and Structure of Small-Molecule Stabilizer of 14-3-3 Protein-Protein Interactions. Angew. Chem. Int. Ed., 49(24): 4129-4132

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2009

Hennig, S.,  Strauss, H., Vanselow, K., Yildiz, Ö., Schulze, S., Arens, J., Kramer, A. and Wolf, E. 2009. Structural and Functional Analyses of PAS Domain Interactions of the Clock Proteins Drosophila PERIOD and Mouse PERIOD2. PLoS Biology, 7(4): e94

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2007

Schöning, J. C., Streitner, C., Page, D. R., Hennig, S., Uchida, K., Wolf, E., Furuay, M. and Staiger, D. 2007. Autoegulation of the circadian slave oscillator component AtGRP7 and regulation of its targets is impaired by a single RNA recognition motif point mutation.  Plant J., 52(6):1119–1130.

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Berndt, A., Kottke, T., Breitkreuz, H., Dvorsky, R., Hennig, S., Alexander, M. and Wolf, E. 2007. A Novel Photoreaction Mechanism for the Circadian Blue Light Photoreceptor Drosophila Cryptochrome. J. Biol. Chem., 282(17):13011–13021.

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2005

Yildiz, Ö., Doi, M., Yujnovsky, I., Cardone, L., Berndt, A., Hennig, S., Schulze, S., Urbanke, C., Sassone–Corsi, P. and Wolf, E.* 2005. Crystal Structure and Interactions of the PAS Repeat Region of the Drosophila Clock Protein PERIOD. Mol. Cell, 17(1):69–82.

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