Research Articles


Durukan, C., Arbore, F., Klintrot, R., Bigiotti, C., Ilie, I., M., Vreede, J., Grossmann, T., N.,* Hennig, S.* 2024.

Binding dynamics of a stapled peptide targeting the transcription factor NF-Y. 

Chem. Bio. Chem.., e202400020. doi: 10.1002/cbic.202400020.

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McLoughlin, N. M., Albers, M. A., Collado Camps, E., Paulus, J., Ran, Y., A., Neubacher, S., Hennig, S., Brock, R., Grossmann*, T. N. 2023.

Environment-Responsive Peptide Dimers Bind and Stabilize Double-Stranded RNA. 

Angew. Chem. Int. Ed., 62(41):e202308028. doi: 10.1002/anie.202308028.

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Preschel, H. D., Otte, R. T., Zhuo, Y., Ruscoe, R. E., Burke, A. J., Kellerhals, R., Horst, B., Hennig, S., Janssen, E., Green, A. P., Turner, N. J., Ruijter*, E. 2023.

Multicomponent Synthesis of the SARS-CoV-2 Main Protease Inhibitor Nirmatrelvir. 

J. Org. Chem., 88(17):12565-12571. doi: 10.1021/acs.joc.3c01274.

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Kiehstaller, S., Hutchins, G. H., Amore, A., Gerber, A., Ibrahim, M., Hennig, S., Neubacher*, S., and Grossmann*, T., N. 2023.

Bicyclic Engineered Sortase A Performs Transpeptidation under Denaturing Conditions. 

Bioconjugate Chem., 34(6): 1114–1121. doi: 10.1021/acs.bioconjchem.3c00151.

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Horst, B., Verdoorn, D., S., Hennig, S., van der Heijden, G., Ruijter, E.* 2022.

Enantioselective Total Synthesis of (–)-Limaspermidine and (–)-Kopsinine by a Nitroaryl Transfer Cascade Strategy. Angew. Chem. Int. Ed., 61(42):e202210592. doi: g/10.1002/anie.202210592.

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Blanas, A., Karsjens, H., de Ligt, A., Huijbers, E., J., M., van Loon, K., Denisov, S., S., Durukan, C., Engbersen, D., J., M., Groen, J., Hennig, S., Hackeng, T., M., van Beijnum, J., R., Griffioen, A., W.* 2022.

Vaccination with a bacterial peptide conjugated to SARS-CoV-2 receptor-binding domain accelerates immunity and protects against COVID-19. iScience, 25(8):104719. doi: 10.1016/j.isci.2022.104719.

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Richters, A., Hennig, S.* 2021.

Structure-driven approaches and technologies for drug discovery. Drug Discovery Today: Technologies, 40:25-26. doi:10.1016/j.ddtec.2021.11.001.

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Gerhard, L., Hennig, S.* 2021.

FRET Analysis of RNA–Protein Interactions Using Spinach Aptamers. Methods Mol. Biol., 2323:171–197. doi:10.1007/978-1-0716-1499-0_13

  [NCBI PubMed] [Springer]

Wendt, M., Bellavita, R., Gerber, A., Efrém, N., L., Ramshorst, T. v., Pearce, N., M., Davey, P., R., J., Everard, I., Vazquez‑Chantada, M., Chiarparin, E., Grieco, P., Hennig, S., Grossmann, T., N.* 2021.

Bicyclic β-sheet mimetics that target the transcriptional coactivator β-catenin and inhibit Wnt signaling. Angew. Chem. Int. Ed., 133:14056–14063. doi:10.1002/anie.202102082
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Kiehstaller, S., Ottmann, C., Hennig, S.* 2020.
MMP activation–associated aminopeptidase N reveals a bivalent 14-3-3 binding motif. J. Biol. Chem., 295(52):18266–18275. doi:10.1074/jbc.RA120.014708
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Wallraven, K., Holmelin, F. L., Glas, A., Hennig, S., Frolov, A. I.*, Grossmann, T. N.* 2020.
Adapting free energy perturbation simulations for large macrocyclic ligands: How to dissect contributions from direct binding and free ligand flexibility. Chem. Sci., 11, 2269–2276. doi:10.1039/C9SC04705K
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Lunk, I., Litty, F.-A., Hennig, S., Vetter, I. R., Kotthaus, J., Altmann, K. S., Ott, G., Havemeyer, A., Garcia, C. C., Clement, B., Schade, D.* 2020.
Discovery of N-(4-Aminobutyl)-N’-(2-methoxyethyl)guanidine as the First Selective, Nonamino Acid, Catalytic Site Inhibitor of Human Dimethylaminohydrolase ( hDDAH-1). J. Med. Chem., 63(1):425-432. doi: 10.1021/acs.jmedchem.9b01230
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Jeganathan, S., Wendt, M., Kiehstaller, S., Brancaccio, D., Kuepper, A., Pospiech, N., Carotenuto, A., Novellino, E., Hennig, S.*, Grossmann, T. N.* 2019.

Constrained peptides with fine-tuned flexibility inhibits NF-Y transcription factor assembly. Angew. Chem. Int. Ed., 58:2-10.
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Hennig, S.*, Neubacher, S.* 2019.
Fluorescent RNA tags: current and future applications. Fut. Med. Chem., 11(19):2483-2485.
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Neubacher, S., Hennig, S., Grossmann, T. N.* 2019.
Organisch-chemisch stabilisierte Enzyme für eine nachhaltige Wirtschaft. BIOspektrum, 25(3):338-339, doi: 10.1007/s12268-019-1039-5.
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Neubacher, S., Hennig, S.* 2019.
RNA Structure and Cellular Applications of Fluorescent Light-Up Aptamers. Angew. Chem. Int. Ed., 131:1278-1291, doi: 10.1002/anie.201806482.
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Pelay-Gimeno, M., Bange, T., Hennig, S., Grossmann, T., N.* 2018.
In Situ Cyclization of Native Proteins: Structure-Based Design of a Bicyclic Enzyme. Angew. Chem. Int. Ed., 57(35):11164-11170, doi: 10.1002/anie.201804506.
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Pospiech, N., Cibis, H., Dietrich, L., Müller, F., Bange, T., Hennig, S.* 2018.
Identification of novel PANDAR protein interaction partners involved in splicing regulation. Sci. Rep., 8(1):2798, doi: 10.1038/s41598-018-21105-6.

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Roszyk, L., Kollenda, S., Hennig, S.* 2017.
Using a specific RNA-protein interaction to quench the fluorescent RNA Spinach. ACS Chem. Biol., 12(12):2958-2964.
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Krüger, D.M., Glas, A., Bier, D., Pospiech, N., Wallraven, K., Dietrich, L., Ottmann, C., Koch, O.*, Hennig, S.*, Grossmann, T., N.* 2017.
Structure-Based Design of Non-Natural Macrocyclic Peptides that Inhibit Protein-Protein Interactions. J. Med. Chem., 60:8982-8988 doi: 10.1021/acs.jmedchem.7b01221.

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Hennig, S., Kong, G., Mannen, T., Sadowska, A., Kobelke, S., Blythe, A., Knott, G.J., Iyer, K.S., Ho, D., Newcombe, E.A., Hosoki, K., Goshima, N., Kawaguchi, T., Hatters, D., Trinkle-Mulcahy, L., Hirose, T., Bond, C.S., Fox, A.H. 2015.
Prion-like domains in RNA binding proteins are essential for building subnuclear paraspeckles. J. Cell Biol., 210(4):529-539
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Lee, C.U., Hahne, G., Hanske, J., Bange, T., Bier, D., Rademacher, C., Hennig, S., Grossmann, T. N. 2015.
Redox Modulation of PTEN Phosphatase Activity by Hydrogen Peroxide and Bisperoxidovanadium Complexes. Angew. Chem. Int. Ed., 54(46):13796-13800
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Chakravarty, D., Sboner, A., Nair, S., S., Giannopoulou, E., Li, R., Hennig, S., Mosquera, J., M., Pauwels, J., Park, K., Kossai, M., MacDonald, T., Y., Fontugne, J., Erho, N., Vergara, I., A., Ghadessi, M., Davicioni, E., Jenkins, R., B., Palanisamy, N., Chen, Z., Nakagawa, S., Hirose, T., Bander, N., H., Beltran, H., Fox, A., H., Elemento, O., Rubin, M., A. 2014.
The oestrogen receptor alpha-regulated lncRNA NEAT1 is a critical modulator of prostate cancer. Nature Comm., 5(5383):1-16

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Milroy, L., Grossmann, T. N., Hennig, S., Brunsveld, L. and Ottmann, C. 2014.
Modulators of Protein−Protein Interactions. Chem. Rev., 114(9):4695-748

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Thiel, P., Röglin, L., Meissner, N., Hennig, S.,* Kohlbacher, O.* and Ottmann, C.* 2013.
Virtual screening and experimental validation reveal novel small-molecule inhibitors of 14-3-3 protein–protein interactions. Chem. Comm., 49(76):8468-70

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Kucera, N., Schmalen, I., Hennig, S., Strauss, H., Grudziecki, A., Wieczorek, C., Kramer, A. and Wolf, E. 2012. Unwinding the Differences of the Mammalian PERIOD Proteins from Crystal Structure to Cellular Function. PNAS, 109(9):3311-3316

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Lee, M., Passon, D. M., Hennig, S., Fox, A. H. and Bond, C., S. 2011. Construct optimization for studying protein complexes: obtaining diffraction-quality crystals of the pseudosymmetric PSPC1–NONO heterodimer. Acta Cryst. D, D67: 981–987

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Rose, R., Erdmann, S., Bovens, S., Wolf, A., Rose, S., Hennig, S., Waldmann, H. and Ottmann, C. 2010. Identification and Structure of Small-Molecule Stabilizer of 14-3-3 Protein-Protein Interactions. Angew. Chem. Int. Ed., 49(24): 4129-4132

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Hennig, S.,  Strauss, H., Vanselow, K., Yildiz, Ö., Schulze, S., Arens, J., Kramer, A. and Wolf, E. 2009. Structural and Functional Analyses of PAS Domain Interactions of the Clock Proteins Drosophila PERIOD and Mouse PERIOD2. PLoS Biology, 7(4): e94

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Schöning, J. C., Streitner, C., Page, D. R., Hennig, S., Uchida, K., Wolf, E., Furuay, M. and Staiger, D. 2007. Autoegulation of the circadian slave oscillator component AtGRP7 and regulation of its targets is impaired by a single RNA recognition motif point mutation.  Plant J., 52(6):1119–1130.

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Berndt, A., Kottke, T., Breitkreuz, H., Dvorsky, R., Hennig, S., Alexander, M. and Wolf, E. 2007. A Novel Photoreaction Mechanism for the Circadian Blue Light Photoreceptor Drosophila Cryptochrome. J. Biol. Chem., 282(17):13011–13021.

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Yildiz, Ö., Doi, M., Yujnovsky, I., Cardone, L., Berndt, A., Hennig, S., Schulze, S., Urbanke, C., Sassone–Corsi, P. and Wolf, E.* 2005. Crystal Structure and Interactions of the PAS Repeat Region of the Drosophila Clock Protein PERIOD. Mol. Cell, 17(1):69–82.

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