Research Articles


Blanas, A., Karsjens, H., de Ligt, A., Huijbers, E., J., M., van Loon, K., Denisov, S., S., Durukan, C., Engbersen, D., J., M., Groen, J., Hennig, S., Hackeng, T., M., van Beijnum, J., R., Griffioen, A., W.* 2022.

Vaccination with a bacterial peptide conjugated to SARS-CoV-2 receptor-binding domain accelerates immunity and protects against COVID-19. iScience, 25(8):104719. doi: 10.1016/j.isci.2022.104719.

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Richters, A., Hennig, S.* 2021.

Structure-driven approaches and technologies for drug discovery. Drug Discovery Today: Technologies, 40, 25-26. doi:10.1016/j.ddtec.2021.11.001.

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Gerhard, L., Hennig, S.* 2021.

FRET Analysis of RNA–Protein Interactions Using Spinach Aptamers. Methods Mol. Biol., 2323:171–197. doi:10.1007/978-1-0716-1499-0_13

  [NCBI PubMed] [Springer]

Wendt, M., Bellavita, R., Gerber, A., Efrém, N., L., Ramshorst, T. v., Pearce, N., M., Davey, P., R., J., Everard, I., Vazquez‑Chantada, M., Chiarparin, E., Grieco, P., Hennig, S., Grossmann, T., N.* 2021.

Bicyclic β-sheet mimetics that target the transcriptional coactivator β-catenin and inhibit Wnt signaling. Angew. Chem. Int. Ed., 133:14056–14063. doi:10.1002/anie.202102082
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Kiehstaller, S., Ottmann, C., Hennig, S.* 2020.
MMP activation–associated aminopeptidase N reveals a bivalent 14-3-3 binding motif. J. Biol. Chem., 295(52):18266–18275. doi:10.1074/jbc.RA120.014708
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Wallraven, K., Holmelin, F. L., Glas, A., Hennig, S., Frolov, A. I.*, Grossmann, T. N.* 2020.
Adapting free energy perturbation simulations for large macrocyclic ligands: How to dissect contributions from direct binding and free ligand flexibility. Chem. Sci., 11, 2269–2276. doi:10.1039/C9SC04705K
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Lunk, I., Litty, F.-A., Hennig, S., Vetter, I. R., Kotthaus, J., Altmann, K. S., Ott, G., Havemeyer, A., Garcia, C. C., Clement, B., Schade, D.* 2020.
Discovery of N-(4-Aminobutyl)-N’-(2-methoxyethyl)guanidine as the First Selective, Nonamino Acid, Catalytic Site Inhibitor of Human Dimethylaminohydrolase ( hDDAH-1). J. Med. Chem., 63(1):425-432. doi: 10.1021/acs.jmedchem.9b01230
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Jeganathan, S., Wendt, M., Kiehstaller, S., Brancaccio, D., Kuepper, A., Pospiech, N., Carotenuto, A., Novellino, E., Hennig, S.*, Grossmann, T. N.* 2019.

Constrained peptides with fine-tuned flexibility inhibits NF-Y transcription factor assembly. Angew. Chem. Int. Ed., 58:2-10.
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Hennig, S.*, Neubacher, S.* 2019.
Fluorescent RNA tags: current and future applications. Fut. Med. Chem., 11(19):2483-2485.
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Neubacher, S., Hennig, S., Grossmann, T. N.* 2019.
Organisch-chemisch stabilisierte Enzyme für eine nachhaltige Wirtschaft. BIOspektrum, 25(3):338-339, doi: 10.1007/s12268-019-1039-5.
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Neubacher, S., Hennig, S.* 2019.
RNA Structure and Cellular Applications of Fluorescent Light-Up Aptamers. Angew. Chem. Int. Ed., 131:1278-1291, doi: 10.1002/anie.201806482.
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Pelay-Gimeno, M., Bange, T., Hennig, S., Grossmann, T., N.* 2018.
In Situ Cyclization of Native Proteins: Structure-Based Design of a Bicyclic Enzyme. Angew. Chem. Int. Ed., 57(35):11164-11170, doi: 10.1002/anie.201804506.
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Pospiech, N., Cibis, H., Dietrich, L., Müller, F., Bange, T., Hennig, S.* 2018.
Identification of novel PANDAR protein interaction partners involved in splicing regulation. Sci. Rep., 8(1):2798, doi: 10.1038/s41598-018-21105-6.

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Roszyk, L., Kollenda, S., Hennig, S.* 2017.
Using a specific RNA-protein interaction to quench the fluorescent RNA Spinach. ACS Chem. Biol., 12(12):2958-2964.
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Krüger, D.M., Glas, A., Bier, D., Pospiech, N., Wallraven, K., Dietrich, L., Ottmann, C., Koch, O.*, Hennig, S.*, Grossmann, T., N.* 2017.
Structure-Based Design of Non-Natural Macrocyclic Peptides that Inhibit Protein-Protein Interactions. J. Med. Chem., 60:8982-8988 doi: 10.1021/acs.jmedchem.7b01221.

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Hennig, S., Kong, G., Mannen, T., Sadowska, A., Kobelke, S., Blythe, A., Knott, G.J., Iyer, K.S., Ho, D., Newcombe, E.A., Hosoki, K., Goshima, N., Kawaguchi, T., Hatters, D., Trinkle-Mulcahy, L., Hirose, T., Bond, C.S., Fox, A.H. 2015.
Prion-like domains in RNA binding proteins are essential for building subnuclear paraspeckles. J. Cell Biol., 210(4):529-539
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Lee, C.U., Hahne, G., Hanske, J., Bange, T., Bier, D., Rademacher, C., Hennig, S., Grossmann, T. N. 2015.
Redox Modulation of PTEN Phosphatase Activity by Hydrogen Peroxide and Bisperoxidovanadium Complexes. Angew. Chem. Int. Ed., 54(46):13796-13800
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Chakravarty, D., Sboner, A., Nair, S., S., Giannopoulou, E., Li, R., Hennig, S., Mosquera, J., M., Pauwels, J., Park, K., Kossai, M., MacDonald, T., Y., Fontugne, J., Erho, N., Vergara, I., A., Ghadessi, M., Davicioni, E., Jenkins, R., B., Palanisamy, N., Chen, Z., Nakagawa, S., Hirose, T., Bander, N., H., Beltran, H., Fox, A., H., Elemento, O., Rubin, M., A. 2014.
The oestrogen receptor alpha-regulated lncRNA NEAT1 is a critical modulator of prostate cancer. Nature Comm., 5(5383):1-16

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Milroy, L., Grossmann, T. N., Hennig, S., Brunsveld, L. and Ottmann, C. 2014.
Modulators of Protein−Protein Interactions. Chem. Rev., 114(9):4695-748

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Thiel, P., Röglin, L., Meissner, N., Hennig, S.,* Kohlbacher, O.* and Ottmann, C.* 2013.
Virtual screening and experimental validation reveal novel small-molecule inhibitors of 14-3-3 protein–protein interactions. Chem. Comm., 49(76):8468-70

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Kucera, N., Schmalen, I., Hennig, S., Strauss, H., Grudziecki, A., Wieczorek, C., Kramer, A. and Wolf, E. 2012. Unwinding the Differences of the Mammalian PERIOD Proteins from Crystal Structure to Cellular Function. PNAS, 109(9):3311-3316

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Lee, M., Passon, D. M., Hennig, S., Fox, A. H. and Bond, C., S. 2011. Construct optimization for studying protein complexes: obtaining diffraction-quality crystals of the pseudosymmetric PSPC1–NONO heterodimer. Acta Cryst. D, D67: 981–987

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Rose, R., Erdmann, S., Bovens, S., Wolf, A., Rose, S., Hennig, S., Waldmann, H. and Ottmann, C. 2010. Identification and Structure of Small-Molecule Stabilizer of 14-3-3 Protein-Protein Interactions. Angew. Chem. Int. Ed., 49(24): 4129-4132

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Hennig, S.,  Strauss, H., Vanselow, K., Yildiz, Ö., Schulze, S., Arens, J., Kramer, A. and Wolf, E. 2009. Structural and Functional Analyses of PAS Domain Interactions of the Clock Proteins Drosophila PERIOD and Mouse PERIOD2. PLoS Biology, 7(4): e94

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Schöning, J. C., Streitner, C., Page, D. R., Hennig, S., Uchida, K., Wolf, E., Furuay, M. and Staiger, D. 2007. Autoegulation of the circadian slave oscillator component AtGRP7 and regulation of its targets is impaired by a single RNA recognition motif point mutation.  Plant J., 52(6):1119–1130.

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Berndt, A., Kottke, T., Breitkreuz, H., Dvorsky, R., Hennig, S., Alexander, M. and Wolf, E. 2007. A Novel Photoreaction Mechanism for the Circadian Blue Light Photoreceptor Drosophila Cryptochrome. J. Biol. Chem., 282(17):13011–13021.

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Yildiz, Ö., Doi, M., Yujnovsky, I., Cardone, L., Berndt, A., Hennig, S., Schulze, S., Urbanke, C., Sassone–Corsi, P. and Wolf, E.* 2005. Crystal Structure and Interactions of the PAS Repeat Region of the Drosophila Clock Protein PERIOD. Mol. Cell, 17(1):69–82.

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